Precision autophagy directed by receptor regulators–emerging examples within the TRIM family
Selective autophagy entails cooperation between target recognition and assembly of the
autophagic apparatus. Target recognition is conducted by receptors that often recognize …
autophagic apparatus. Target recognition is conducted by receptors that often recognize …
Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines
MI Koukourakis, D Kalamida, A Giatromanolaki… - PloS one, 2015 - journals.plos.org
LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely
used as biomarkers of autophagy. Whether these three LC3 proteins have a similar …
used as biomarkers of autophagy. Whether these three LC3 proteins have a similar …
MG 132‐induced progerin clearance is mediated by autophagy activation and splicing regulation
K Harhouri, C Navarro, D Depetris… - EMBO molecular …, 2017 - embopress.org
Hutchinson–Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging
disease caused by a de novo point mutation in LMNA encoding A‐type lamins. Progerin, a …
disease caused by a de novo point mutation in LMNA encoding A‐type lamins. Progerin, a …
Structure and dynamics in the ATG8 family from experimental to computational techniques
Autophagy is a conserved and essential intracellular mechanism for the removal of
damaged components. Since autophagy deregulation is linked to different kinds of …
damaged components. Since autophagy deregulation is linked to different kinds of …
The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress
MS Shim, A Nettesheim, J Hirt, PB Liton - Autophagy, 2020 - Taylor & Francis
The trabecular meshwork (TM) is a key regulatory tissue of intraocular pressure (IOP) in the
anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous …
anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous …
Nuclear LC3 associates with slowly diffusing complexes that survey the nucleolus
MAP1LC3B (microtubule‐associated protein 1 light chain 3, LC3) is a key component of the
autophagy pathway, contributing to both cargo selection and autophagosome formation in …
autophagy pathway, contributing to both cargo selection and autophagosome formation in …
ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience
N Jiménez-Moreno, M Kollareddy, P Stathakos… - Journal of Cell …, 2023 - rupress.org
The LIM homeodomain transcription factors LMX1A and LMX1B are essential mediators of
midbrain dopaminergic neuronal (mDAN) differentiation and survival. Here we show that …
midbrain dopaminergic neuronal (mDAN) differentiation and survival. Here we show that …
[HTML][HTML] Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone
W Li, Z Luo, CY Yan, XH Wang, ZJ He, SH Ouyang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that can cause a
variety of clinical syndromes including mucocutaneous disease and HSV-1 encephalitis …
variety of clinical syndromes including mucocutaneous disease and HSV-1 encephalitis …
On the Prevalence and Roles of Proteins Undergoing Liquid–Liquid Phase Separation in the Biogenesis of PML-Bodies
SA Silonov, YI Mokin, EM Nedelyaev, EY Smirnov… - Biomolecules, 2023 - mdpi.com
The formation and function of membrane-less organelles (MLOs) is one of the main driving
forces in the molecular life of the cell. These processes are based on the separation of …
forces in the molecular life of the cell. These processes are based on the separation of …
Human promyelocytic leukemia protein is targeted to distinct subnuclear domains in plant nuclei and colocalizes with nucleolar constituents in a SUMO‐dependent …
Eukaryotic nuclei are subdivided into subnuclear structures. Among the most prominent of
these structures are the nucleolus and the PML nuclear bodies (PML‐NB s). PML‐NB s are …
these structures are the nucleolus and the PML nuclear bodies (PML‐NB s). PML‐NB s are …