By permitting direct visualization of the airspaces of the lung, magnetic resonance imaging
(MRI) using hyperpolarized gases provides unique strategies for evaluating pulmonary …

The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …

Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

Purpose To quantitatively compare hyperpolarized helium 3 (3He) and xenon 129 (129Xe)
magnetic resonance (MR) images obtained within 5 minutes in healthy volunteers and …

RATIONALE AND OBJECTIVES: To improve intra-and interobserver variability and enable
the use of functional magnetic resonance imaging (MRI) for multicenter, multiobserver …

The increase in total cross-sectional area in the distal airways of the human lung enhances
the mixing of each tidal breath with end-expiratory gas volume by slowing bulk flow and …

Given its greater availability and lower cost, 129Xe apparent diffusion coefficient (ADC) MRI
offers an alternative to 3He ADC MRI. To demonstrate the feasibility of hyperpolarized …

Purpose To evaluate the safety and tolerability of inhaling multiple 1-L volumes of undiluted
hyperpolarized xenon 129 (129Xe) followed by up to a 16-second breath hold and magnetic …

Lung diseases affect the conducting airways, the gas exchange parenchyma, or both. As a
result, they have a high impact on patients' morbidity, and quality of life. Chronic obstructive …

This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …