[HTML][HTML] Venous overload choroidopathy: a hypothetical framework for central serous chorioretinopathy and allied disorders

RF Spaide, CMG Cheung, H Matsumoto, S Kishi… - Progress in retinal and …, 2022 - Elsevier
In central serous chorioretinopathy (CSC), the macula is detached because of fluid leakage
at the level of the retinal pigment epithelium. The fluid appears to originate from choroidal …

Direct human health risks of increased atmospheric carbon dioxide

TA Jacobson, JS Kler, MT Hernke, RK Braun… - Nature …, 2019 - nature.com
Growing evidence suggests that environmentally relevant elevations in CO2 (< 5,000 ppm)
may pose direct risks for human health. Increasing atmospheric CO2 concentrations could …

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

FE Garrett-Bakelman, M Darshi, SJ Green, RC Gur… - Science, 2019 - science.org
INTRODUCTION To date, 559 humans have been flown into space, but long-duration (> 300
days) missions are rare (n= 8 total). Long-duration missions that will take humans to Mars …

Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

AG Lee, TH Mader, CR Gibson, W Tarver, P Rabiei… - npj …, 2020 - nature.com
Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual
physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity …

Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest

SS Laurie, SMC Lee, BR Macias, N Patel… - JAMA …, 2020 - jamanetwork.com
Importance Optic disc edema develops in astronauts during long-duration spaceflight and is
a risk for all future astronauts during spaceflight. Having a ground-based analogue of …

Head-down tilt bed rest studies as a terrestrial analog for spaceflight associated neuro-ocular syndrome

J Ong, AG Lee, HE Moss - Frontiers in Neurology, 2021 - frontiersin.org
Astronauts who undergo prolonged periods of spaceflight may develop a unique
constellation of neuro-ocular findings termed Spaceflight Associated Neuro-Ocular …

Ground-based analogs for human spaceflight

M Pandiarajan, AR Hargens - Frontiers in physiology, 2020 - frontiersin.org
This mini-review provides an updated summary of various analogs for adaptations of
humans to the microgravity of space. Microgravity analogs discussed in this paper include …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation

A Robin, A Van Ombergen, C Laurens… - Nature …, 2023 - nature.com
Astronauts in microgravity experience multi-system deconditioning, impacting their inflight
efficiency and inducing dysfunctions upon return to Earth gravity. To fill the sex gap of …

Neuro-ophthalmic imaging and visual assessment technology for spaceflight associated neuro-ocular syndrome (SANS)

J Ong, A Tavakkoli, G Strangman, N Zaman… - survey of …, 2022 - Elsevier
Spaceflight associated neuro-ocular syndrome (SANS) refers to a unique collection of neuro-
ophthalmic clinical and imaging findings observed in astronauts after long-duration …