Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies

G Limorenko, HA Lashuel - Chemical Society Reviews, 2022 - pubs.rsc.org
Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

RNA splicing regulators play critical roles in neurogenesis

E Fisher, J Feng - Wiley Interdisciplinary Reviews: RNA, 2022 - Wiley Online Library
Alternative RNA splicing increases transcript diversity in different cell types and under
varying conditions. It is executed with the help of RNA splicing regulators (RSRs), which are …

RNAInter in 2020: RNA interactome repository with increased coverage and annotation

Y Lin, T Liu, T Cui, Z Wang, Y Zhang, P Tan… - Nucleic acids …, 2020 - academic.oup.com
Research on RNA-associated interactions has exploded in recent years, and increasing
numbers of studies are not limited to RNA–RNA and RNA–protein interactions but also …

lncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma

W Zhu, J Wang, X Liu, Y Xu, R Zhai, J Zhang… - Cell death & …, 2022 - nature.com
Oral squamous cell carcinoma (OSCC), the most common malignancy of the oral and
maxillofacial region, severely affects human health. However, current treatments for OSCC …

RNA structure drives interaction with proteins

N Sanchez de Groot, A Armaos… - Nature …, 2019 - nature.com
The combination of high-throughput sequencing and in vivo crosslinking approaches leads
to the progressive uncovering of the complex interdependence between cellular …

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

OJ Ziff, J Harley, Y Wang, J Neeves, G Tyzack… - Neuron, 2023 - cell.com
Amyotrophic lateral sclerosis (ALS) is characterized by nucleocytoplasmic mislocalization of
the RNA-binding protein (RBP) TDP-43. However, emerging evidence suggests more …

Structural analysis of SARS-CoV-2 genome and predictions of the human interactome

A Vandelli, M Monti, E Milanetti, A Armaos… - Nucleic acids …, 2020 - academic.oup.com
Specific elements of viral genomes regulate interactions within host cells. Here, we
calculated the secondary structure content of> 2000 coronaviruses and computed> 100 000 …

Long noncoding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models

X Tang, Y Luo, D Yuan, R Calandrelli… - The Journal of …, 2023 - Am Soc Clin Investig
Impaired angiogenesis in diabetes is a key process contributing to ischemic diseases such
as peripheral arterial disease. Epigenetic mechanisms, including those mediated by long …

catRAPID omics v2.0: going deeper and wider in the prediction of protein–RNA interactions

A Armaos, A Colantoni, G Proietti, J Rupert… - Nucleic Acids …, 2021 - academic.oup.com
Prediction of protein–RNA interactions is important to understand post-transcriptional events
taking place in the cell. Here we introduce cat RAPID omics v2. 0, an update of our web …

ORC1 binds to cis-transcribed RNAs for efficient activation of replication origins

AM Mas, E Goñi, I Ruiz de Los Mozos, A Arcas… - Nature …, 2023 - nature.com
Cells must coordinate the activation of thousands of replication origins dispersed throughout
their genome. Active transcription is known to favor the formation of mammalian origins …