Targeting ROS in cancer: rationale and strategies

C Glorieux, S Liu, D Trachootham… - Nature Reviews Drug …, 2024 - nature.com
Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

B Pajak, E Siwiak, M Sołtyka, A Priebe… - International journal of …, 2019 - mdpi.com
The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates
that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and …

[HTML][HTML] Red blood cell storage lesion: causes and potential clinical consequences

T Yoshida, M Prudent, A D'Alessandro - Blood Transfusion, 2019 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

EB Kurutas - Nutrition journal, 2015 - Springer
Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated in the
etiology of numerous human diseases. Oxidative/Nitrosative stress is the result of an …

Targeting breast cancer stem cell state equilibrium through modulation of redox signaling

M Luo, L Shang, MD Brooks, E Jiagge, Y Zhu… - Cell metabolism, 2018 - cell.com
Although breast cancer stem cells (BCSCs) display plasticity transitioning between
quiescent mesenchymal-like (M) and proliferative epithelial-like (E) states, how this plasticity …

Hydrogen peroxide–production, fate and role in redox signaling of tumor cells

C Lennicke, J Rahn, R Lichtenfels… - Cell communication and …, 2015 - Springer
Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

[HTML][HTML] Red blood cells: the forgotten player in hemostasis and thrombosis

JW Weisel, RI Litvinov - Journal of Thrombosis and Haemostasis, 2019 - Elsevier
New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role
of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review …

Molecular mechanisms and clinical implications of the gold drug auranofin

S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Y Zhang, Q Li, Z Huang, B Li, EC Nice, C Huang, L Wei… - Cancers, 2022 - mdpi.com
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Role of red blood cells in haemostasis and thrombosis

RI Litvinov, JW Weisel - ISBT science series, 2017 - Wiley Online Library
In contrast to an obsolete notion that erythrocytes, or red blood cells (RBC s), play a passive
and minor role in haemostasis and thrombosis, over the past decades there has been …