Mycobacterial dormancy systems and host responses in tuberculosis

V Peddireddy, SN Doddam, N Ahmed - Frontiers in immunology, 2017 - frontiersin.org
Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

Cell wall: A versatile fountain of drug targets in Mycobacterium tuberculosis

ZS Bhat, MA Rather, M Maqbool, HUL Lah… - Biomedicine & …, 2017 - Elsevier
Tuberculosis is the leading infectious disease responsible for an estimated one and a half
million human deaths each year around the globe. HIV-TB coinfection and rapid increase in …

[HTML][HTML] Drug targets exploited in Mycobacterium tuberculosis: Pitfalls and promises on the horizon

ZS Bhat, MA Rather, M Maqbool, Z Ahmad - Biomedicine & …, 2018 - Elsevier
Tuberculosis is an ever evolving infectious disease that still claims about 1.8 million human
lives each year around the globe. Although modern chemotherapy has played a pivotal role …

High proportion of RR-TB and mutations conferring RR outside of the RRDR of the rpoB gene detected in GeneXpert MTB/RIF assay positive pulmonary tuberculosis …

GT Akalu, B Tessema, B Petros - Plos one, 2022 - journals.plos.org
Background Globally, TB is the leading cause of infectious disease morbidity and mortality
with many diagnostic uncertainties. Access to affordable and rapid diagnostics remained a …

Application of three-dimensional (3D) tumor cell culture systems and mechanism of drug resistance

A Shehzad, V Ravinayagam… - Current …, 2019 - ingentaconnect.com
The in-vitro experimental model for the development of cancer therapeutics has always
been challenging. Recently, the scientific revolution has improved cell culturing techniques …

Ethambutol targets the glutamate racemase of Mycobacterium tuberculosis—an enzyme involved in peptidoglycan biosynthesis

A Pawar, P Jha, C Konwar, U Chaudhry… - Applied microbiology …, 2019 - Springer
Increasing drug resistance in pathogens including Mycobacterium tuberculosis (MTB) has
been ascribed to mutations in the known target genes. However, many of these drugs have …

Bolstering immunity through pattern recognition receptors: a unique approach to control tuberculosis

S Pahari, G Kaur, M Aqdas, S Negi… - Frontiers in …, 2017 - frontiersin.org
The global control of tuberculosis (TB) presents a continuous health challenge to mankind.
Despite having effective drugs, TB still has a devastating impact on human health …

[PDF][PDF] Special issue “Antimicrobial biomaterials: recent progress”

HP Felgueiras - International Journal of Molecular Sciences, 2024 - mdpi.com
Biomaterials have demonstrated their ability to serve as effective drug delivery platforms,
enabling targeted and localized administration of therapeutic agents. The development of …

Alginate nanoparticles: a potential drug carrier in tuberculosis treatment

RP Patel, GK Patel, N Patel, S Singh… - Tubercular drug Delivery …, 2023 - Springer
Among all infectious diseases that afflict humans, tuberculosis (TB) remains the deadliest. At
present, epidemiologists estimate that one-third of the world population is infected with …

[HTML][HTML] Synthesis and biological evaluation of copper and cobalt complexes of (5-substituted-salicylidene) isonicotinichydrazide derivatives as antitubercular agents

CU Dueke-Eze, TM Fasina, AE Oluwalana… - Scientific African, 2020 - Elsevier
Cobalt (II) and copper (II) complexes of a series (E)-N'-(5-X-salicylidene)
isonicotinohydrazide Schiff bases derived from isonicotinic acid hydrazide and 5-substituted …