For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Apoptosis is a sequential order of cell death occurring regularly to ensure a homeostatic
balance between the rate of cell formation and cell death. However, a misplaced of this …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Cell death pathways have evolved to maintain tissue homoeostasis and eliminate potentially
harmful cells from within an organism, such as cells with damaged DNA that could lead to …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Abstract During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial
permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that
simultaneously bind to a target protein and an E3 ligase, thereby leading to ubiquitination …

Jun N-terminal kinases or JNKs have been shown to be involved in a wide array of signaling
events underlying tumorigenesis and tumor progression. Through its interaction with a …