Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

Hemidesmosomes are multiprotein complexes that facilitate the stable adhesion of basal
epithelial cells to the underlying basement membrane. The mechanical stability of …

Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …

Inherited epidermolysis bullosa is a group of genetic diseases characterized by skin fragility
and blistering on the skin and mucous membranes in response to minimal trauma …

Despite their importance in cell biology, the mechanisms that maintain the nucleus in its
proper position in the cell are not well understood. This is primarily the result of an …

Cells recognize and respond to their extracellular environment through transmembrane
receptors such as integrins, which physically connect the extracellular matrix to the …

Hemidesmosomes are multiprotein adhesion complexes that promote epithelial stromal
attachment in stratified and complex epithelia. Modulation of their function is of crucial …

The plakin family consists of giant proteins involved in the cross-linking and organization of
the cytoskeleton and adhesion complexes. They further modulate several fundamental …

Plakins are large multi-domain molecules that have various functions to link cytoskeletal
elements together and to connect them to junctional complexes. Plakins were first identified …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …