Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis
Y Li, J Wang, L Li, W Song, M Li, X Hua… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Pentacyclic triterpenoids are important natural bioactive substances
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …
that are widely present in plants and fungi. They have significant medicinal efficacy, play an …
Betulin and its derivatives as novel compounds with different pharmacological effects
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity
and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of …
and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of …
Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives
Viral infections cause many serious human diseases with high mortality rates. New drug‐
resistant strains are continually emerging due to the high viral mutation rate, which makes it …
resistant strains are continually emerging due to the high viral mutation rate, which makes it …
Biological and pharmacological effects of synthetic saponins
Saponins are amphiphilic molecules consisting of carbohydrate and either triterpenoid or
steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal …
steroid aglycone moieties and are noted for their multiple biological activities—Fungicidal …
[HTML][HTML] The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions
AA Gomaa, YA Abdel-Wadood - Phytomedicine plus, 2021 - Elsevier
Background Several recent studies have stated that glycyrrhizin and licorice extract are
present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China …
present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China …
The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
[HTML][HTML] Chemical constituents and pharmacological activities of medicinal plants from Rosa genus
Y Wang, Y Zhao, X Liu, J Li, J Zhang, D Liu - Chinese herbal medicines, 2022 - Elsevier
Abstract The genus Rosa (Rosaceae family) includes about 200 species spread in the
world, and this genus shows unique advantages in medicine and food. To date, several …
world, and this genus shows unique advantages in medicine and food. To date, several …
Generation of influenza A viruses as live but replication-incompetent virus vaccines
The conversion of life-threatening viruses into live but avirulent vaccines represents a
revolution in vaccinology. In a proof-of-principle study, we expanded the genetic code of the …
revolution in vaccinology. In a proof-of-principle study, we expanded the genetic code of the …
Discovery of pentacyclic triterpenoid PROTACs as a class of effective hemagglutinin protein degraders
H Li, S Wang, W Ma, B Cheng, Y Yi, X Ma… - Journal of Medicinal …, 2022 - ACS Publications
Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is
an up-and-coming antiviral drug target. Herein, we described for the first time the design …
an up-and-coming antiviral drug target. Herein, we described for the first time the design …