Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …

Engineering of smart building molecules is key basis in designing intelligent drug delivery
systems. As an emerging sophisticated delivery system strategy, the powerful functions of …

Fracture nonunion remains a great challenge for orthopedic surgeons. Fracture repair
comprises of three phases, the inflammatory, repair and remodeling stage. Extensive …

Immunogenic responses by protein therapeutics often lead to reduced therapeutic effects
and/or adverse effects via the generation of neutralizing antibodies and/or antidrug …

Diabetes-associated bone complications lead to fragile bone mechanical strength and
osteoporosis, aggravating the disease burden of patients. Advanced evidence shows that …

With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the
clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient …

Fracture healing is a complex physiological process in which angiogenesis plays an
essential role. Microfibril-associated glycoprotein-2 (MAGP2) has been reported to possess …

Currently available biotherapeutics for the treatment of osteoporosis lack explicit
mechanisms for bone localization, potentially limiting efficacy and inducing unintended off …

Highlights•Small molecules have been proposed as alternatives to regenerate bone
tissue.•Small molecule drug dose can often be reduced while still achieving effective …

Targeted drug delivery, often referred to as “smart” drug delivery, is a process whereby a
therapeutic drug is delivered to specific parts of the body in a manner that increases its …