Aldose reductase and protein tyrosine phosphatase 1B inhibitors as a promising therapeutic approach for diabetes mellitus
A Kousaxidis, A Petrou, V Lavrentaki… - European Journal of …, 2020 - Elsevier
Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …
Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic …
Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar
levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase …
levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase …
Recent developments in the practical application of novel carboxylic acid bioisosteres
C Horgan, TP O'Sullivan - Current Medicinal Chemistry, 2022 - ingentaconnect.com
Background: The carboxylic acid moiety is an important functional group which features in
the pharmacophore of some 450 drugs. Unfortunately, some carboxylic acid-containing …
the pharmacophore of some 450 drugs. Unfortunately, some carboxylic acid-containing …
Pyrrole-2, 5-dione analogs as a promising antioxidant agents: microwave-assisted synthesis, bio-evaluation, SAR analysis and DFT studies/interpretation
A new series of pyrrole analogs were developed via the microwave irradiation synthesis.
Consequently, got a high yield of the products. As pyrroles are familiar for showing various …
Consequently, got a high yield of the products. As pyrroles are familiar for showing various …
Non-acidic bifunctional benzothiazole-based thiazolidinones with antimicrobial and aldose reductase inhibitory activity as a promising therapeutic strategy for sepsis
A Kousaxidis, L Kovacikova, I Nicolaou… - Medicinal Chemistry …, 2021 - Springer
Sepsis is a life-threatening disease that affects millions of people worldwide. Microbial
infections that lead to sepsis syndrome are associated with an increased production of …
infections that lead to sepsis syndrome are associated with an increased production of …
Discovery of a novel benzothiadiazine-based selective aldose reductase inhibitor as potential therapy for diabetic peripheral neuropathy
R Jin, J Wang, M Li, T Tang, Y Feng, S Zhou, H Xie… - Diabetes, 2024 - Am Diabetes Assoc
Aldose reductase 2 (ALR2), an activated enzyme in the polyol pathway by hyperglycemia,
has long been recognized as one of the most promising targets for complications of …
has long been recognized as one of the most promising targets for complications of …
Novel rhodanine based inhibitors of aldose reductase of non-acidic nature with p-hydroxybenzylidene functional group
M Kratky, P Sramel, P Bodo, MS Prnova… - European Journal of …, 2023 - Elsevier
Aldose reductase, the first enzyme of the polyol pathway represents a key drug target in
therapy of diabetic complications. In this study a series of six novel rhodanine based …
therapy of diabetic complications. In this study a series of six novel rhodanine based …
Development of non-acidic 4-methylbenzenesulfonate-based aldose reductase inhibitors; Design, Synthesis, biological evaluation and in-silico studies
Abstract Design and virtual screening of a set of non-acidic 4-methyl-4-phenyl-
benzenesulfonate-based aldose reductase 2 inhibitors had been developed followed by …
benzenesulfonate-based aldose reductase 2 inhibitors had been developed followed by …
Strategies in synthetic design and structure–activity relationship studies of novel heterocyclic scaffolds as aldose reductase‐2 inhibitors
Heterocyclic scaffolds of natural as well as synthetic origin provide almost all categories of
drugs exhibiting a wide range of pharmacological activities, such as antibiotics, antidiabetic …
drugs exhibiting a wide range of pharmacological activities, such as antibiotics, antidiabetic …
Design synthesis and evaluation of novel aldose reductase inhibitors: The case of indolyl–sulfonyl–phenols
K Koutsopoulos, V Lavrentaki, I Antoniou… - Bioorganic & Medicinal …, 2020 - Elsevier
Therapeutic interventions with aldose reductase inhibitors appear to be a promising
approach to major pathological conditions (ie neuropathy/angiopathy related to chronic …
approach to major pathological conditions (ie neuropathy/angiopathy related to chronic …