The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are
transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal …

Mammalian chromosome duplication progresses in a precise order and is subject to
constraints that are often relaxed in developmental disorders and malignancies. Molecular …

Genome sequences have been determined for many model organisms; however, repetitive
regions such as centromeres, telomeres, and subtelomeres have not yet been sequenced …

Sequencing of cancer genomes has identified recurrent somatic mutations in histones,
termed oncohistones, which are frequently poorly understood. Previously we showed that …

The subtelomere, a telomere-adjacent chromosomal domain, contains species-specific
homologous DNA sequences, in addition to various genes. However, the functions of …

The histone chaperone FACT and histone H2B ubiquitination (H2Bub) facilitate RNA
polymerase II (Pol II) passage through chromatin, yet it is not clear how they cooperate …

Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate
K27M or G34R/V mutant histone H3. 3. H3. 3-G34R/V mutants are common in tumors with …

The ATRX ATP-dependent chromatin remodelling/helicase protein associates with the
DAXX histone chaperone to deposit histone H3. 3 over repetitive DNA regions. Because …

Quiescent cells require a continuous supply of proteins to maintain protein homeostasis. In
fission yeast, entry into quiescence is triggered by nitrogen stress, leading to the inactivation …

The recruitment of RNA polymerase II (Pol II) to core promoters is highly regulated during
rapid induction of genes. In response to heat shock, heat shock transcription factor 1 (HSF 1) …