The best-known role of UDP-glucuronosyltransferase enzymes (UGTs) in cancer is the
metabolic inactivation of drug therapies. By conjugating glucuronic acid to lipophilic drugs …

Simple Summary The human UDP-glycosyltransferase (UGT) superfamily plays a critical
role in the metabolism of numerous endogenous and exogenous small lipophilic …

The androgen inactivating UGT2B28 pathway emerges as a predictor of progression in
prostate cancer (PCa). However, the clinical significance of UGT2B28 tumoral expression …

Nucleotide sugar-dependent glycosyltransferases (UGTs) are critical to the homeostasis of
endogenous metabolites and the detoxification of xenobiotics. Their impact on the cell …

Background: The pervasive role of alternative promoters in context-specific isoform
expression and the importance of promoter choice over its level of transcriptional activity …

Background Naturally occurring germline gene deletions (KO) represent a unique setting to
interrogate gene functions. Complete deletions and differential expression of the human …

The drug response sensitivity and related prognosis of prostate cancer varied from races,
while the original mechanism remains rarely understood. In this study, the comprehensive …

Neurosteroids have been associated with neurodegenerative diseases because they are
involved in the modulation of neurotransmitter, neurotropic and neuroprotective actions …

Background High expression of the glycosyltransferase UGT2B17 represents an
independent adverse prognostic marker in chronic lymphocytic leukemia (CLL). It also …

As the era of cancer genomics expands, disproportionate rates of prostate cancer incidence
and mortality by race have demonstrated increasing relevance in clinical settings. While …