Genetic structure of pharmacogenetic biomarkers in Brazil inferred from a systematic review and population-based cohorts: a RIBEF/EPIGEN-Brazil initiative
F Rodrigues-Soares, FSG Kehdy… - The …, 2018 - nature.com
We present allele frequencies involving 39 pharmacogenetic biomarkers studied in Brazil,
and their distribution on self-reported race/color categories that:(1) involve a mix of …
and their distribution on self-reported race/color categories that:(1) involve a mix of …
Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and …
I Fricke-Galindo, H Jung-Cook, A LLerena… - Drug Metabolism and …, 2016 - degruyter.com
Mexico presents a complex population diversity integrated by Mexican indigenous (MI)(7%
of Mexico's population) and Mexican mestizos (MMs). This composition highlights the …
of Mexico's population) and Mexican mestizos (MMs). This composition highlights the …
To genotype or phenotype for personalized medicine? CYP450 drug metabolizing enzyme genotype–phenotype concordance and discordance in the Ecuadorian …
F De Andrés, S Terán, F Hernández… - Omics: a journal of …, 2016 - liebertpub.com
Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing
enzymes confer substantial person-to-person and between-population differences in …
enzymes confer substantial person-to-person and between-population differences in …
Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population
F de Andrés, C Altamirano-Tinoco… - The …, 2021 - nature.com
Interethnic variability in the drug-metabolizing capacity of CYP450 enzymes may lead to
discrepancies in the relationship between genotypes and phenotypes worldwide. The …
discrepancies in the relationship between genotypes and phenotypes worldwide. The …
High frequency of CYP2D6 ultrarapid metabolizers in Spain: controversy about their misclassification in worldwide population studies
MEG Naranjo, F De Andrés, A Delgado… - The …, 2016 - nature.com
Abstract A high frequency (7–10%) of CYP2D6 ultrarapid metabolizers estimated from the
genotype (gUMs) has been claimed to exist among Spaniards and Southern Europeans …
genotype (gUMs) has been claimed to exist among Spaniards and Southern Europeans …
Pharmacogenomic implications of the differential distribution of CYP2C9 metabolic phenotypes among Latin American populations
G Suarez-Kurtz - Frontiers in Pharmacology, 2023 - frontiersin.org
The CYP2C9 gene encodes the major drug metabolism enzyme CYP2C9. This gene is
highly polymorphic, and no-function (CYP2C9* 3) plus decreased function (CYP2C9* 2,* 5 …
highly polymorphic, and no-function (CYP2C9* 3) plus decreased function (CYP2C9* 2,* 5 …
Pharmacogenetics and ethnicity: relevance for clinical implementation, clinical trials, pharmacovigilance and drug regulation in Latin America
Congress of Pharmacogenetics and Personalized Medicine. Ethnicity, clinical
implementation and regulatory environment (MESTIFAR 2016 Quito) Quito, Ecuador, 19–21 …
implementation and regulatory environment (MESTIFAR 2016 Quito) Quito, Ecuador, 19–21 …
Pharmacogenetic research activity in Central America and the Caribbean: a systematic review
C Cespedes-Garro, MEG Naranjo… - …, 2016 - Taylor & Francis
Aim: The present review was aimed at analyzing the pharmacogenetic scientific activity in
Central America and the Caribbean. Materials & methods: A literature search for …
Central America and the Caribbean. Materials & methods: A literature search for …
Pharmacogenetics of healthy volunteers in Puerto Rico
K Claudio-Campos, C Orengo-Mercado… - Drug metabolism and …, 2015 - degruyter.com
Puerto Ricans are a unique Hispanic population with European, Native American (Taino),
and higher West African ancestral contributions than other non-Caribbean Hispanics. In …
and higher West African ancestral contributions than other non-Caribbean Hispanics. In …
Relevance of the ancestry for the variability of the Drug-Metabolizing Enzymes CYP2C9, CYP2C19 and CYP2D6 polymorphisms in a multiethnic Costa Rican …
C Céspedes-Garro, F Rodrigues-Soares… - Revista de biologia …, 2016 - scielo.sa.cr
CYP2C9, CYP2C19 and CYP2D6 metabolize around 40% of drugs and their genes vary
across populations. The Costa Rican population has a trihybrid ancestry and its key …
across populations. The Costa Rican population has a trihybrid ancestry and its key …