The vertebrate retina is a well-characterized and tractable model for studying neurogenesis.
Retinal neurons and glia are generated in a conserved sequence from a pool of multipotent …

The vertebrate eye comprises tissues from different embryonic origins: the lens and the
cornea are derived from the surface ectoderm, but the retina and the epithelial layers of the …

Loss of photoreceptors due to retinal degeneration is a major cause of blindness in the
developed world. While no effective treatment is currently available, cell replacement …

The scarcity of embryonic/foetal material as a resource for direct study means that there is
still limited understanding of human retina development. Here, we present an integrated …

During tissue and organ development and maintenance, the dynamic regulation of cellular
proliferation and differentiation allows cells to build highly elaborate structures. The …

Time is neither an entity nor a process and hence, cannot be measured and defined. In
physical terms, however, the temporal measurement is observed in the form of the output …

Development in the central nervous system is highly dependent on the regulation of the
switch from progenitor cell proliferation to differentiation, but the molecular and cellular …

Reactive oxygen species (ROS) and downstream products of lipid oxidation are emerging
as important secondary messengers in tissue homeostasis. However, their regulation and …

Inherited retinal degenerations (IRD) affecting either photoreceptors or pigment epithelial
cells cause progressive visual loss and severe disability, up to complete blindness. Retinal …

Purpose: The neurohormones melatonin and dopamine mediate clock-dependent/circadian
regulation of inner retinal neurons and photoreceptor cells and in this way promote their …