High-density lipoproteins, reverse cholesterol transport and atherogenesis

HJ Pownall, C Rosales, BK Gillard… - Nature Reviews …, 2021 - nature.com
Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic
cardiovascular disease (ASCVD). According to a widely cited model, HDL elicits its …

Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis

PJ Barter, HB Brewer Jr, MJ Chapman… - … , and vascular biology, 2003 - Am Heart Assoc
Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from
antiatherogenic HDLs to proatherogenic apolipoprotein B (apoB)–containing lipoproteins …

High density lipoproteins and arteriosclerosis: role of cholesterol efflux and reverse cholesterol transport

A Von Eckardstein, JR Nofer… - … , thrombosis, and vascular …, 2001 - Am Heart Assoc
High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart
disease, and HDL exerts various potentially antiatherogenic properties, including the …

Unique lipoprotein phenotype and genotype associated with exceptional longevity

N Barzilai, G Atzmon, C Schechter, EJ Schaefer… - Jama, 2003 - jamanetwork.com
ContextIndividuals with exceptional longevity have a lower incidence and/or significant
delay in the onset of age-related disease, and their family members may inherit biological …

Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk

A Thompson, E Di Angelantonio, N Sarwar, S Erqou… - Jama, 2008 - jamanetwork.com
Context The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary
disease is uncertain. Study of CETP genotypes can help better understand the relevance of …

A review of CETP and its relation to atherosclerosis

GJ de Grooth, AHEM Klerkx, ESG Stroes… - Journal of lipid …, 2004 - ASBMB
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective
therapeutics to selectively increase plasma HDL-c levels are not yet available. Recent …

Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis

CW Rittershaus, DP Miller, LJ Thomas… - … , and vascular biology, 2000 - Am Heart Assoc
Using a vaccine approach, we immunized New Zealand White rabbits with a peptide
containing a region of cholesteryl ester transfer protein (CETP) known to be required for …

Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene

B Agerholm-Larsen, BG Nordestgaard, R Steffensen… - Circulation, 2000 - Am Heart Assoc
Background—The level of HDL cholesterol is inversely related to the risk of ischemic heart
disease. Methods and Results—In 9168 women and men from a general population and …

New functional promoter polymorphism, CETP/− 629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol …

C Dachet, O Poirier, F Cambien… - … , and vascular biology, 2000 - Am Heart Assoc
A new polymorphism located at position− 629 (CETP/− 629A/C) in the promoter of the
cholesteryl ester transfer protein (CETP) gene is described. The− 629A allele was …

Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease

SM Boekholdt, JF Thompson - Journal of lipid research, 2003 - ASBMB
Since the identification of cholesteryl ester transfer protein (CETP), its role in the modulation
of HDL levels and cardiovascular disease has been debated. With the early detection of …