Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Photosensitizers with aggregation‐induced emission: materials and biomedical applications

F Hu, S Xu, B Liu - Advanced materials, 2018 - Wiley Online Library
Photodynamic therapy is arising as a noninvasive treatment modality for cancer and other
diseases. One of the key factors to determine the therapeutic function is the efficiency of …

The future of bioorthogonal chemistry

NK Devaraj - ACS central science, 2018 - ACS Publications
Bioorthogonal reactions have found widespread use in applications ranging from glycan
engineering to in vivo imaging. Researchers have devised numerous reactions that can be …

Beyond the margins: real-time detection of cancer using targeted fluorophores

RR Zhang, AB Schroeder, JJ Grudzinski… - Nature reviews Clinical …, 2017 - nature.com
Over the past two decades, synergistic innovations in imaging technology have resulted in a
revolution in which a range of biomedical applications are now benefiting from fluorescence …

Click chemistry in complex mixtures: bioorthogonal bioconjugation

CS McKay, MG Finn - Chemistry & biology, 2014 - cell.com
The selective chemical modification of biological molecules drives a good portion of modern
drug development and fundamental biological research. While a few early examples of …

Developing bioorthogonal probes to span a spectrum of reactivities

SS Nguyen, JA Prescher - Nature Reviews Chemistry, 2020 - nature.com
Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …

Fluorine-18 radiochemistry, labeling strategies and synthetic routes

O Jacobson, DO Kiesewetter, X Chen - Bioconjugate chemistry, 2015 - ACS Publications
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET)
radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear …

Smart chemistry-based nanosized drug delivery systems for systemic applications: a comprehensive review

T Ramasamy, HB Ruttala, B Gupta, BK Poudel… - Journal of Controlled …, 2017 - Elsevier
This review focuses on the smart chemistry that has been utilized in developing polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

N Kamaly, Z Xiao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …

Achieving controlled biomolecule–biomaterial conjugation

CD Spicer, ET Pashuck, MM Stevens - Chemical reviews, 2018 - ACS Publications
The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …