Fir (e) ing the rhythm: inflammatory cytokines and cardiac arrhythmias

PE Lazzerini, A Abbate, M Boutjdir… - Basic to Translational …, 2023 - jacc.org
Inflammatory activation is increasingly recognized as a nonconventional risk factor for
arrhythmias, and experimental studies provided robust evidence that this association is …

Genetic and molecular aspects of drug-induced QT interval prolongation

D Baracaldo-Santamaría, K Llinás-Caballero… - International Journal of …, 2021 - mdpi.com
Long QT syndromes can be either acquired or congenital. Drugs are one of the many
etiologies that may induce acquired long QT syndrome. In fact, many drugs frequently used …

Cardiac corrected QT interval changes among patients treated for COVID-19 infection during the early phase of the pandemic

GA Rubin, AD Desai, Z Chai, A Wang, Q Chen… - JAMA network …, 2021 - jamanetwork.com
Importance Critical illness, a marked inflammatory response, and viruses such as SARS-
CoV-2 may prolong corrected QT interval (QTc). Objective To evaluate baseline QTc interval …

Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases

X Zhu, Y Wang, Y Xiao, Q Gao, L Gao, W Zhang… - Scientific Reports, 2022 - nature.com
Inflammatory diseases including COVID-19 are associated with a cytokine storm
characterized by high interleukin-6 (IL-6) titers. In particular, while recent studies examined …

Cardiotoxic potential of hydroxychloroquine, chloroquine and azithromycin in adult human primary cardiomyocytes

P Jordaan, B Dumotier, M Traebert… - Toxicological …, 2021 - academic.oup.com
Substantial efforts have been recently committed to develop coronavirus disease-2019
(COVID-19) medications, and Hydroxychloroquine alone or in combination with …

Prolonged QT predicts prognosis in COVID‐19

Z Akhtar, MM Gallagher, YG Yap… - Pacing and Clinical …, 2021 - Wiley Online Library
Abstract Background Coronavirus disease‐2019 (COVID‐19) causes severe illness and
multi‐organ dysfunction. An abnormal electrocardiogram is associated with poor outcome …

An observational, retrospective, comprehensive pharmacovigilance analysis of hydroxychloroquine-associated cardiovascular adverse events in patients with and …

M Luo, B Wu, Y Li, F Wu - International journal of clinical pharmacy, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is a global pandemic.
Hydroxychloroquine (HCQ)-associated cardiovascular adverse events (CVAEs) have been …

Interleukin-6 elevation is a key pathogenic factor underlying COVID-19-associated heart rate-corrected QT interval prolongation

PE Lazzerini, R Accioli, M Acampa… - Frontiers in …, 2022 - frontiersin.org
Background Heart rate-corrected QT interval (QTc) prolongation is prevalent in patients with
severe coronavirus disease 2019 (COVID-19) and is associated with poor outcomes. Recent …

COVID-19, hydroxychloroquine and sudden cardiac death: implications for clinical practice in patients with rheumatic diseases

HA Raza, J Tariq, V Agarwal, L Gupta - Rheumatology International, 2021 - Springer
Sudden cardiac death is commonly seen due to arrhythmias, which is a common cardiac
manifestation seen in COVID-19 patients, especially those with underlying cardiovascular …

Lethal Arrhythmia (Torsade de Pointes) in COVID-19: An Event Synergistically Induced by Viral Associated Cardiac Injury, Hyperinflammatory Response, and …

N Yasmin Kusumawardhani, I Huang… - Clinical Medicine …, 2020 - journals.sagepub.com
Arrhythmias in patients with coronavirus disease 2019 (COVID-19) are prevalent and
deserve special attention because they are associated with an increased risk of fatal …