Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …

The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to
contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to …

Background: In human heart failure, Ser199 (equivalent to Ser200 in mouse) of cTnI (cardiac
troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that it enhances …

cTnIP82S (cTnIP83S in rodents) resides at the IT arm of cardiac troponin I (cTnI) and was
initially identified as a disease-causing mutation of hypertrophic cardiomyopathy (HCM) …

Myocardial remodeling in response to chronic myocardial infarction (CMI) progresses
through two phases, hypertrophic “compensation” and congestive “decompensation.” …

Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in
multiple animal models of inherited cardiomyopathy. These signaling alterations together …

The β1-adrenergic regulation of cardiac myocyte contraction plays an important role in
regulating heart function. Activation of this system leads to an increased heart rate and …

Hypertrophic cardiomyopathy is the most common monogenic disorder in cardiology.
Despite important advances in understanding disease pathogenesis, it is not clear how …

In der vorliegenden Arbeit wurde der differentialdiagnostische Wert von kardialen
Biomarkern verschiedener Entitäten-namentlich die hochsensitiven Troponine T und I …

Background This study evaluates the associations between high-sensitivity troponin I and T
(hs-TnI/hs-TnT) and the stages of heart failure with preserved ejection fraction …