The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …

Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous studies have
identified several genetic loci associated with typical AF. We sought to identify common …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

Abstract Ca2+-activated K+ (KCa) channels of small (SK) and intermediate (IK) conductance
are present in a wide range of excitable and non-excitable cells. On activation by low …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Action potentials in many central neurons are followed by a prolonged
afterhyperpolarization (AHP) that influences firing frequency and affects neuronal …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

Calcium-activated potassium channels modulate calcium signaling cascades and
membrane potential in both excitable and non-excitable cells. In this article we will review …

The three small-conductance calcium-activated potassium (KCa2) channels and the related
intermediate-conductance KCa3. 1 channel are voltage-independent K+ channels that …