Breast density implications and supplemental screening

A Vourtsis, WA Berg - European radiology, 2019 - Springer
Digital breast tomosynthesis (DBT) has been widely implemented in place of 2D
mammography, although it is less effective in women with extremely dense breasts. Breast …

Consensus guidelines on genetictesting for hereditary breast cancer from the American Society of Breast Surgeons

ER Manahan, HM Kuerer, M Sebastian… - Annals of surgical …, 2019 - Springer
Background The purpose of this consensus guideline is to outline recommendations for
genetic testing that medical professionals can use to assess hereditary risk for breast …

Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

K Kast, K Rhiem, B Wappenschmidt… - Journal of medical …, 2016 - jmg.bmj.com
Purpose To characterise the prevalence of pathogenic germline mutations in BRCA1 and
BRCA2 in families with breast cancer (BC) and ovarian cancer (OC) history. Patients and …

Breast cancer induced by X-ray mammography screening? A review based on recent understanding of low-dose radiobiology

EKJ Pauwels, N Foray, MH Bourguignon - Medical Principles and …, 2016 - karger.com
Screening mammography offers the possibility of discovering malignant diseases at an early
stage, which is consequently treated early, thereby reducing the mortality rate. However …

High-risk breast cancer surveillance with MRI: 10-year experience from the German consortium for hereditary breast and ovarian cancer

U Bick, C Engel, B Krug, W Heindel… - Breast cancer research …, 2019 - Springer
Purpose To report on 10 years of high-risk service screening with annual MRI in the German
Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Methods A cohort of …

Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2 and RAD51C Status

JM Cunningham, MS Cicek, NB Larson, J Davila… - Scientific reports, 2014 - nature.com
We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian
cancer (EOC) considering BRCA1, BRCA2 and RAD51C in a large well-annotated patient …

Multigene Panel Testing Detects Equal Rates of Pathogenic BRCA1/2 Mutations and has a Higher Diagnostic Yield Compared to Limited BRCA1/2 Analysis Alone in …

NS Kapoor, LD Curcio, CA Blakemore… - Annals of surgical …, 2015 - Springer
Background Recently introduced multigene panel testing including BRCA1 and BRCA2
genes for hereditary cancer risk has raised concerns with the ability to detect all deleterious …

The risk of contralateral breast cancer in patients from BRCA1/2 negative high risk families as compared to patients from BRCA1 or BRCA2 positive families: a …

K Rhiem, C Engel, M Graeser, S Zachariae… - Breast Cancer …, 2012 - Springer
Introduction While it has been reported that the risk of contralateral breast cancer in patients
from BRCA1 or BRCA2 positive families is elevated, little is known about contralateral breast …

Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variants

S Jervis, H Song, A Lee, E Dicks, J Tyrer… - Journal of medical …, 2014 - jmg.bmj.com
Background Family history is one of the most important risk factors for epithelial ovarian
cancer (EOC). Little is known, however, on how EOC familial relative risks (FRRs) vary by …

BRCA mutations and their influence on pathological complete response and prognosis in a clinical cohort of neoadjuvantly treated breast cancer patients

M Wunderle, P Gass, L Häberle, VM Flesch… - Breast cancer research …, 2018 - Springer
Purpose BRCA1/2 mutations influence the molecular characteristics and the effects of
systemic treatment of breast cancer. This study investigates the impact of germline BRCA1/2 …