Acute kidney injury (AKI) is a common complication in cardiac surgery patients, with a
reported incidence of 20 to 30%. The development of AKI is associated with worse short-and …

The acute loss of kidney function has been diagnosed for many decades using the serum
concentration of creatinine—a muscle metabolite that is an insensitive and non-specific …

Oxygen is essential for the maintenance of the body. Living organisms have evolved
systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays …

Perioperative hypotension is common and associated with poor outcomes, including acute
kidney injury (AKI). The mechanistic link between perioperative hypotension and AKI is at …

Background Acute kidney injury (AKI) is a common complication of cardiac surgery. An intra-
operative monitor of kidney perfusion is needed to identify patients at risk for AKI. We …

Norepinephrine is the principal vasopressor used to restore blood pressure in sepsis, but its
effects on intrarenal oxygenation are unknown. To clarify this, we examined renal cortical …

Chronic kidney disease (CKD) is a major public health problem. Accumulating evidence
suggests that CKD aggravates renal hypoxia, and in turn, renal hypoxia accelerates CKD …

Background Acute kidney injury (AKI) is common after cardiac surgery and profoundly
affects postoperative mortality and morbidity. There are no validated methods to assess risk …

Acute kidney injury (AKI) is a common complication following cardiac surgery performed on
cardiopulmonary bypass (CPB) and has important implications for prognosis. The aetiology …

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue
oxygenation has been linked to its pathogenesis. Moreover, renal medullary tissue hypoxia …