Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

A new era for space life science: international standards for space omics processing

L Rutter, R Barker, D Bezdan, H Cope, SV Costes… - Patterns, 2020 - cell.com
Space agencies have announced plans for human missions to the Moon to prepare for
Mars. However, the space environment presents stressors that include radiation …

Understanding reduced gravity effects on early plant development before attempting life-support farming in the moon and mars

FJ Medina, A Manzano, A Villacampa… - Frontiers in Astronomy …, 2021 - frontiersin.org
Plants are a necessary component of any system of bioregenerative life-support for human
space exploration. For this purpose, plants must be capable of surviving and adapting to …

Epigenomic Regulators Elongator Complex Subunit 2 and Methyltransferase 1 Differentially Condition the Spaceflight Response in Arabidopsis

AL Paul, N Haveman, B Califar, RJ Ferl - Frontiers in Plant Science, 2021 - frontiersin.org
Background: Plants subjected to the novel environment of spaceflight show transcriptomic
changes that resemble aspects of several terrestrial abiotic stress responses. Under …

From Spaceflight to Mars g-Levels: Adaptive Response of A. Thaliana Seedlings in a Reduced Gravity Environment Is Enhanced by Red-Light Photostimulation

A Villacampa, M Ciska, A Manzano… - International Journal of …, 2021 - mdpi.com
The response of plants to the spaceflight environment and microgravity is still not well
understood, although research has increased in this area. Even less is known about plants' …

Functional meta-analysis of the proteomic responses of arabidopsis seedlings to the spaceflight environment reveals multi-dimensional sources of variability across …

GO Olanrewaju, CPS Kruse, SE Wyatt - International Journal of Molecular …, 2023 - mdpi.com
The human quest for sustainable habitation of extraterrestrial environments necessitates a
robust understanding of life's adaptability to the unique conditions of spaceflight. This study …

Recent transcriptomic studies to elucidate the plant adaptive response to spaceflight and to simulated space environments

A Manzano, E Carnero-Diaz, R Herranz, FJ Medina - Iscience, 2022 - cell.com
Discovering the adaptation mechanisms of plants to the space environment is essential for
supporting human space exploration. Transcriptomic analyses allow the identification of …

Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight

EG Overbey, S Das, H Cope, P Madrigal… - Cell reports …, 2022 - cell.com
Single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) have
experienced rapid development in recent years. The findings of spaceflight-based scRNA …

Conserved plant transcriptional responses to microgravity from two consecutive spaceflight experiments

ES Land, J Sheppard, CJ Doherty… - Frontiers in Plant …, 2024 - frontiersin.org
Introduction Understanding how plants adapt to the space environment is essential, as
plants will be a valuable component of long duration space missions. Several spaceflight …

Test of Arabidopsis Space Transcriptome: A Discovery Environment to Explore Multiple Plant Biology Spaceflight Experiments

R Barker, J Lombardino, K Rasmussen… - Frontiers in Plant …, 2020 - frontiersin.org
Recent advances in the routine access to space along with increasing opportunities to
perform plant growth experiments on board the International Space Station have led to an …