The recent acceleration of commercial, private and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …

Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …

Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Abstract Background The Inspiration4 (I4) mission, the first all-civilian orbital flight mission,
investigated the physiological effects of short-duration spaceflight through a multi-omic …

Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for
maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long …

Human space exploration poses inherent risks to astronauts' health, leading to molecular
changes that can significantly impact their well-being. These alterations encompass …

Human spaceflight has historically been managed by government agencies, such as in the
NASA Twins Study, but new commercial spaceflight opportunities have opened spaceflight …