Fundamentals of the intrinsic DNA fluorescence

T Gustavsson, D Markovitsi - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus The intrinsic fluorescence of nucleic acids is extremely weak compared to that
of the fluorescent labels used to probe their structural and functional behavior. Thus, for …

How nature covers its bases

S Boldissar, MS de Vries - Physical Chemistry Chemical Physics, 2018 - pubs.rsc.org
The response of DNA and RNA bases to ultraviolet (UV) radiation has been receiving
increasing attention for a number of important reasons:(i) the selection of the building blocks …

Electronic delocalization, charge transfer and hypochromism in the UV absorption spectrum of polyadenine unravelled by multiscale computations and quantitative …

JJ Nogueira, F Plasser, L González - Chemical science, 2017 - pubs.rsc.org
The characterization of the electronically excited states of DNA strands populated upon solar
UV light absorption is essential to unveil light-induced DNA damage and repair processes …

Multiple electronic and structural factors control cyclobutane pyrimidine dimer and 6–4 thymine–thymine photodimerization in a DNA duplex

I Conti, L Martínez‐Fernández… - … A European Journal, 2017 - Wiley Online Library
The T–T photodimerization paths leading to the formation of cyclobutane pyrimidine dimer
(CPD) and 6–4 pyrimidine pyrimidone (64‐PP), the two main DNA photolesions, have been …

DNA as UV light–harvesting antenna

IL Volkov, ZV Reveguk, PY Serdobintsev… - Nucleic acids …, 2018 - academic.oup.com
The ordered structure of UV chromophores in DNA resembles photosynthetic light-
harvesting complexes in which quantum coherence effects play a major role in highly …

Adenine radicals generated in alternating AT duplexes by direct absorption of low-energy UV radiation

A Banyasz, T Ketola, L Martínez-Fernández… - Faraday …, 2018 - pubs.rsc.org
There is increasing evidence that the direct absorption of photons with energies that are
lower than the ionization potential of nucleobases may result in oxidative damage to DNA …

Dual Time-Scale Proton Transfer and High-Energy, Long-Lived Excitons Unveiled by Broadband Ultrafast Time-Resolved Fluorescence in Adenine–Uracil RNA …

RCT Chan, C Ma, AKW Wong, CTL Chan… - The Journal of …, 2022 - ACS Publications
In contrast to the immense amount of research on electronically excited DNA, surprisingly
little has been done about the excited states of RNA. Herein, we demonstrate an ultrafast …

The ubiquity of high-energy nanosecond fluorescence in DNA duplexes

T Gustavsson, D Markovitsi - The Journal of Physical Chemistry …, 2023 - ACS Publications
During the past few years, several studies reported that a significant part of the intrinsic
fluorescence of DNA duplexes decays with surprisingly long lifetimes (1–3 ns) at …

Radicals generated in alternating guanine–cytosine duplexes by direct absorption of low-energy UV radiation

A Banyasz, L Martinez-Fernandez, R Improta… - Physical Chemistry …, 2018 - pubs.rsc.org
Recent studies have evidenced that oxidatively damaged DNA, which potentially leads to
carcinogenic mutations and aging, may result from the direct absorption of low-energy …

On the Use of the Intrinsic DNA Fluorescence for Monitoring Its Damage: A Contribution from Fundamental Studies

D Markovitsi - ACS omega, 2024 - ACS Publications
The assessment of DNA damage by means of appropriate fluorescent probes is widely
spread. In the specific case of UV-induced damage, it has been suggested to use the …