IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

While modernization has dramatically increased lifespan, it has also witnessed the nature of
stress has changed dramatically. Chronic stress result failures of homeostasis and thus lead …

The success of immune checkpoint blockade in patients with a wide variety of malignancies
has changed the treatment paradigm in oncology. However, combination therapies with …

In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

The enhancement of immune responses upon treatment with immune checkpoint inhibitors
can have the desired outcome of reinvigorating antitumour immune surveillance, but often at …

Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint
blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages …

Despite remarkable improvements in cancer treatment approaches, breast cancer is still the
main cause of cancer-related death in women. Its principal cause is the resistance of the …

Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …

Within the tumor microenvironment, IL-6 signaling is generally considered a malevolent
player, assuming a dark visage that promotes tumor progression. Chronic IL-6 signaling is …