The γ-aminobutyric acid (GABA) system plays a pivotal role in orchestrating the
synchronicity of local networks and the functional coupling of different brain regions. Here …

During mammalian ontogenesis, the neurotransmitter GABA is a fundamental regulator of
neuronal networks. In neuronal development, GABAergic signaling regulates neural …

Down syndrome (DS) is the most frequent genetic cause of intellectual disability, and altered
GABAergic transmission through Cl−-permeable GABAA receptors (GABAARs) contributes …

Down syndrome (DS) is the most common genetic cause of intellectual disability. Protein
homeostasis is essential for normal brain function, but little is known about its role in DS …

Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …

Down syndrome (DS) is the most common genetic cause of mental disability. Based on the
homology of Hsa21 and the murine chromosomes Mmu16, Mmu17 and Mmu10, several …

Cognitive impairment in Down syndrome (DS) is characterized by deficient learning and
memory. Mouse genetic models of DS exhibit impaired cognition in hippocampally mediated …

Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …