[HTML][HTML] Recent advances in chalcone-triazole hybrids as potential pharmacological agents
Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …
compound by combining two or more pharmacophoric units. Being a linkage process, it …
Current scenario of chalcone hybrids with antibreast cancer therapeutic applications
H Wang, J Zhu, Q Zhang, J Tang… - Archiv der …, 2024 - Wiley Online Library
Breast cancer, an epithelial malignant tumor that occurs in the terminal ducts of the breast, is
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …
Design and synthesis of new dihydropyrimidine derivatives with a cytotoxic effect as dual EGFR/VEGFR-2 inhibitors
We developed and synthesized tetrahydropyrimidine derivatives as possible cytotoxic
agents to inhibit EGFR and VEGFR-2 in the present study. Our study completely assesses …
agents to inhibit EGFR and VEGFR-2 in the present study. Our study completely assesses …
In-silico design, pharmacophore-based screening, and molecular docking studies reveal that benzimidazole-1,2,3-triazole hybrids as novel EGFR inhibitors targeting …
Lung cancer is a complex and heterogeneous disease, which has been associated with
various molecular alterations, including the overexpression and mutations of the epidermal …
various molecular alterations, including the overexpression and mutations of the epidermal …
Isatin-semicarbazone linked acetamide 1, 2, 3-triazole hybrids: Synthesis, antimicrobial evaluation and docking simulations
N-Heterocycles stand out in medicinal chemistry as significant pharmacophores because of
their wide biological potential and structural diversity. In this perspective, we have …
their wide biological potential and structural diversity. In this perspective, we have …
Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR …
A series of novel 3-cyanopyridone/pyrazoline hybrids (21–30) exhibiting dual inhibition
against EGFR and BRAFV600E has been developed. The synthesized target compounds …
against EGFR and BRAFV600E has been developed. The synthesized target compounds …
Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5-a]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR
LH Al-Wahaibi, SM Rabea, MA Mahmoud… - ACS …, 2024 - ACS Publications
A series of 1, 2, 4-triazolo [1, 5-a] pyrimidine-based derivatives were developed and
prepared by reacting chalcones 8a–p with 3-phenyl-1, 2, 4-triazole-5-amine (5). The novel …
prepared by reacting chalcones 8a–p with 3-phenyl-1, 2, 4-triazole-5-amine (5). The novel …