[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines

Z Hussain, T Uyama, K Tsuboi, N Ueda - Biochimica et Biophysica Acta …, 2017 - Elsevier
Bioactive N-acylethanolamines (NAEs) are ethanolamides of long-chain fatty acids,
including palmitoylethanolamide, oleoylethanolamide and anandamide. In animal tissues …

The rise and fall of anandamide: processes that control synthesis, degradation, and storage

RG Biringer - Molecular and cellular biochemistry, 2021 - Springer
Anandamide is an endocannabinoid derived from arachidonic acid-containing membrane
lipids and has numerous biological functions. Its effects are primarily mediated by the …

Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia

SMK Rahman, Z Hussain, K Morito, N Takahashi… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract N-Acyl-phosphatidylethanolamines (NAPEs), a minor class of membrane
glycerophospholipids, accumulate along with their bioactive metabolites, N …

An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism

T Uyama, K Tsuboi, N Ueda - FEBS letters, 2017 - Wiley Online Library
The H‐Ras‐like suppressor (HRASLS) is a protein family consisting of five members in
humans. Despite their discovery as tumor suppressors, we demonstrated that all these …

PLAAT1 deficiency alleviates high‐fat diet‐induced hepatic lipid accumulation in mice

SMK Rahman, S Sasaki, T Uyama… - The FASEB …, 2023 - Wiley Online Library
The phospholipase A and acyltransferase (PLAAT) family is composed of three isoforms in
mice (PLAAT1, 3, and 5), all of which function as phospholipid‐metabolizing enzymes …

Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase

Z Hussain, T Uyama, K Kawai, SSB Mustafiz… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract N-acyl-phosphatidylethanolamine (NAPE) is known to be a precursor for various
bioactive N-acylethanolamines including the endocannabinoid anandamide. NAPE is …

PLAAT5 as an N-acyltransferase responsible for the generation of anti-inflammatory N-acylethanolamines in testis

MM Sikder, S Sasaki, Y Miki, Y Nagasaki, K Ohta… - … et Biophysica Acta (BBA …, 2025 - Elsevier
N-Acylethanolamines (NAEs) are a class of lipid mediators that exhibit anti-inflammatory and
appetite-suppressive activities. Among them, palmitoylethanolamide (PEA) and …

Gene loss and relaxed selection of plaat1 in vertebrates adapted to low-light environments

DH Drabeck, J Wiese, E Gilbertson… - … of the Royal …, 2024 - royalsocietypublishing.org
Gene loss is an important mechanism for evolution in low-light or cave environments where
visual adaptations often involve a reduction or loss of eyesight. The plaat gene family …

PLAAT1 exhibits phosphatidylcholine: monolysocardiolipin transacylase activity

RM Bradley, A Hashemi, JJ Aristizabal-Henao… - International Journal of …, 2022 - mdpi.com
Tissue-specific cardiolipin fatty acyl profiles are achieved by remodeling of de novo
synthesized cardiolipin, and four remodeling enzymes have thus far been identified. We …