Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading

M Kjaer - Physiological reviews, 2004 - journals.physiology.org
Kjær, Michael. Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to
Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev. 00031.2003.—The …

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

PP Provenzano, PJ Keely - Journal of cell science, 2011 - journals.biologists.com
The notion that cell shape and spreading can regulate cell proliferation has evolved over
several years, but only recently has this been linked to forces from within and upon the cell …

Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle

SB Wilkinson, SM Phillips, PJ Atherton… - The journal of …, 2008 - Wiley Online Library
Resistance (RE) and endurance (EE) exercise stimulate mixed skeletal muscle protein
synthesis. The phenotypes induced by RE (myofibrillar protein accretion) and EE …

Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences

NA Burd, JE Tang, DR Moore… - Journal of applied …, 2009 - journals.physiology.org
Muscle contraction during exercise, whether resistive or endurance in nature, has profound
affects on muscle protein turnover that can persist for up to 72 h. It is well established that …

Molecular basis of skeletal muscle plasticity-from gene to form and function

M Flück, H Hoppeler - Reviews of physiology, biochemistry and …, 2003 - Springer
Skeletal muscle shows an enormous plasticity to adapt to stimuli such as contractile activity
(endurance exercise, electrical stimulation, denervation), loading conditions (resistance …

Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion

EI Glover, SM Phillips, BR Oates, JE Tang… - The Journal of …, 2008 - Wiley Online Library
We tested the hypothesis that increasing blood amino acid (AA) availability would counter
the physical inactivity‐induced reduction in muscle protein synthesis. We determined how …

Control of the size of the human muscle mass

MJ Rennie, H Wackerhage, EE Spangenburg… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract This review is divided into two parts, the first dealing with the cell and molecular
biology of muscle in terms of growth and wasting and the second being an account of …

Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

MD Boppart, ZS Mahmassani - American Journal of …, 2019 - journals.physiology.org
The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

Alterations of protein turnover underlying disuse atrophy in human skeletal muscle

SM Phillips, EI Glover… - Journal of applied …, 2009 - journals.physiology.org
Unloading-induced atrophy is a relatively uncomplicated form of muscle loss, dependent
almost solely on the loss of mechanical input, whereas in disease states associated with …

The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse

MD De Boer, A Selby, P Atherton, K Smith… - The Journal of …, 2007 - Wiley Online Library
We hypothesized that rates of myofibrillar and patellar tendon collagen synthesis would fall
over time during disuse, the changes being accompanied in muscle by decreases in focal …