Increased prevalence, severity, and burden of anxiety, trauma-related and stress-related
disorders in women compared with men has been well documented. Evidence from a variety …

Estradiol is the “prototypic” sex hormone of women. Yet, women have another sex hormone,
which is often disregarded: Progesterone. The goal of this article is to provide a …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …

The decline observed during aging involves multiple factors that influence several systems.
It is the case for learning and memory processes which are severely reduced with aging. It is …

Objective: In this conceptual review, the authors propose a novel mechanistic candidate in
the etiology of depression with onset in the menopause transition (“perimenopausal …

Postpartum depression (PPD) is a unique subtype of major depressive disorder and a
substantial contributor to maternal morbidity and mortality. In addition to affecting the mother …

In this article, we examine evidence supporting the role of reproductive steroids in the
regulation of mood and behavior in women and the nature of that role. In the first half of the …

Certain women experience negative mood symptoms during the menstrual cycle and
progesterone addition in estrogen treatments. In women with PMDD increased negative …

Our previous analyses showed that allopregnanolone (APα) significantly increased
proliferation of rodent and human neural progenitor cells in vitro. In this study, we …