The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

Mammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels
in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal …

Ca2+ mobilization from intracellular stores represents an important cell signalling process
that is regulated, in mammalian cells, by inositol-1, 4, 5-trisphosphate (InsP3), cyclic ADP …

Endosomes, lysosomes and lysosome-related organelles are emerging as important Ca2+
storage cellular compartments with a central role in intracellular Ca2+ signalling …

The pyridine nucleotides NAD and NADP play vital roles in metabolic conversions as signal
transducers and in cellular defence systems. Both coenzymes participate as electron …

CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the
formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a widespread and potent calcium-
mobilizing messenger that is highly unusual in activating calcium channels located on acidic …

Abstract Changes in cytosolic free Ca 2+ concentration ([Ca 2+] c) play a crucial role in the
control of insulin secretion from the electrically excitable pancreatic β-cell. Secretion is …

Research into the biological role of the Ca2+-releasing second messenger NAADP
(nicotinic acid adenine dinucleotide phosphate) has been hampered by a lack of chemical …