[HTML][HTML] Non-sugar sweeteners and cancer: Toxicological and epidemiological evidence

S Pavanello, A Moretto, C La Vecchia… - Regulatory Toxicology …, 2023 - Elsevier
Several toxicological and epidemiological studies were published during the last five
decades on non-sugar sweeteners (NSS) and cancer. Despite the large amount of research …

[HTML][HTML] Critical review of the current literature on the safety of sucralose

BA Magnuson, A Roberts, ER Nestmann - Food and Chemical Toxicology, 2017 - Elsevier
Sucralose is a non-caloric high intensity sweetener that is approved globally for use in foods
and beverages. This review provides an updated summary of the literature addressing the …

Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays

SS Schiffman, EH Scholl, TS Furey… - Journal of Toxicology …, 2023 - Taylor & Francis
The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

[HTML][HTML] Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

SJ Borghoff, SS Cohen, X Jiang, IA Lea… - Food and Chemical …, 2023 - Elsevier
Aspartame has been studied extensively and evaluated for its safety in foods and beverages
yet concerns for its potential carcinogenicity have persisted, driven primarily by animal …

Non-nutritive sweeteners and their impacts on the gut microbiome and host physiology

IL Richardson, SA Frese - Frontiers in Nutrition, 2022 - frontiersin.org
Non-nutritive sweeteners (NNS) are broadly incorporated into foods, especially those
representing a growing share of the beverage market. NNS are viewed as a noncaloric and …

Neuroendocrine and metabolic effects of low-calorie and non-calorie sweeteners

E Moriconi, A Feraco, V Marzolla, M Infante… - Frontiers in …, 2020 - frontiersin.org
Since excessive sugar consumption has been related to the development of chronic
metabolic diseases prevalent in the western world, the use of sweeteners has gradually …

High concentrations of aspartame induce pro-angiogenic effects in ovo and cytotoxic effects in HT-29 human colorectal carcinoma cells

AL Maghiari, D Coricovac, IA Pinzaru, IG Macașoi… - Nutrients, 2020 - mdpi.com
Aspartame (ASP), an artificial sweetener abundantly consumed in recent years in an array of
dietary products, has raised some concerns in terms of toxicity, and it was even suggested a …

Antioxidant activity, nutritional and physicochemical characteristics, and toxicity of minimally refined brown sugar and other sugars

A Azlan, HE Khoo, AAB Sajak… - Food Science & …, 2020 - Wiley Online Library
Minimally refined brown sugar (MRBS) is a brown sugar derived from sugarcane that has a
low glycemic index. This study aimed to determine and compare the antioxidant contents …

Evaluation of long‐term effects of artificial sweeteners on rat brain: A biochemical, behavioral, and histological study

O Erbaş, MA Erdoğan, A Khalilnezhad… - … of biochemical and …, 2018 - Wiley Online Library
The aim of the present study was to compare the effects of artificial sweeteners (aspartame,
saccharin, and sucralose) on rat brain. Twenty‐four adult male Sprague–Dawley rats were …

Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa

Y Hanawa, M Higashiyama, C Kurihara… - Journal of …, 2021 - Wiley Online Library
Abstract Background and Aim The artificial sweetener acesulfame potassium (ACK) is
officially approved as safe for intake and has been used in processed foods. However, ACKs …