Gram-negative antibiotic development has been hindered by a poor understanding of the
types of compounds that can accumulate within these bacteria,. The presence of efflux …

An outer membrane (OM) is the hallmark feature that is often used to distinguish “Gram-
negative” bacteria. Our understanding of how the OM is built rests largely on studies of …

Bacterial lipoproteins (BLPs) decorate the surface of membranes in the cell envelope. They
function in membrane assembly and stability, as enzymes, and in transport. The final …

The outer membrane (OM) of Gram-negative bacteria is the outermost layer of the cell and
serves as permeability barrier against environmental toxins, including antibiotics. The OM is …

The outer membrane (OM) is an essential organelle of Gram-negative bacteria. Lipoproteins
are key to building the OM, performing essential functions in several OM assembly …

There remains a critical need for new antibiotics against multi-drug-resistant Gram-negative
bacteria, a major global threat that continues to impact mortality rates. Lipoprotein signal …

Dear Editor, The ability to employ small molecules to kill pathogenic bacteria and prevent
serious illness or death has been one of mankind's greatest advances, as before the advent …