G Bretones, MD Delgado, J León - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …
Hematopoiesis is a process capable of generating millions of cells every second, as distributed in many cell types. The process is regulated by a number of transcription factors …
MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain …
AR Grayson, EM Walsh, MJ Cameron, J Godec… - Oncogene, 2014 - nature.com
NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …
Abstract c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms …
Chemotherapeutic drugs have a common intent to activate apoptosis in tumor cells. However, master regulators of apoptosis (eg, p53, p16/CDKN2A) are frequently genetically …
D Diolaiti, L McFerrin, PA Carroll… - Biochimica et Biophysica …, 2015 - Elsevier
The transcription factor MYC and its related family members MYCN and MYCL have been implicated in the etiology of a wide spectrum of human cancers. Compared to other …
S Hirose, N Takayama, S Nakamura, K Nagasawa… - Stem cell reports, 2013 - cell.com
The lack of knowledge about the mechanism of erythrocyte biogenesis through self- replication makes the in vitro generation of large quantities of cells difficult. We show that …
Cell cycle stimulation is a major transforming mechanism of Myc oncoprotein. This is achieved through at least three concomitant mechanisms: upregulation of cyclins and Cdks …