[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
are widely expressed and have key roles in gene regulation. Recent studies have begun to …
Functions and properties of nuclear lncRNAs—from systematically mapping the interactomes of lncRNAs
CY Guh, YH Hsieh, HP Chu - Journal of biomedical science, 2020 - Springer
Protein and DNA have been considered as the major components of chromatin. But beyond
that, an increasing number of studies show that RNA occupies a large amount of chromatin …
that, an increasing number of studies show that RNA occupies a large amount of chromatin …
[PDF][PDF] RNA promotes the formation of spatial compartments in the nucleus
RNA, DNA, and protein molecules are highly organized within three-dimensional (3D)
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …
structures in the nucleus. Although RNA has been proposed to play a role in nuclear …
RNAInter v4. 0: RNA interactome repository with redefined confidence scoring system and improved accessibility
J Kang, Q Tang, J He, L Li, N Yang, S Yu… - Nucleic acids …, 2022 - academic.oup.com
Establishing an RNA-associated interaction repository facilitates the system-level
understanding of RNA functions. However, as these interactions are distributed throughout …
understanding of RNA functions. However, as these interactions are distributed throughout …
Cohesin-dependence of neuronal gene expression relates to chromatin loop length
Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …
ecDNA hubs drive cooperative intermolecular oncogene expression
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …
expression of oncogenes through gene amplification and altered gene regulation. Gene …
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
Whole-genome sequencing of longitudinal tumor pairs representing transformation of
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …
follicular lymphoma to high-grade B cell lymphoma with MYC and BCL2 rearrangements …
MYC reshapes CTCF-mediated chromatin architecture in prostate cancer
Z Wei, S Wang, Y Xu, W Wang, F Soares… - Nature …, 2023 - nature.com
MYC is a well characterized oncogenic transcription factor in prostate cancer, and CTCF is
the main architectural protein of three-dimensional genome organization. However, the …
the main architectural protein of three-dimensional genome organization. However, the …
Regulatory non-coding RNAs: everything is possible, but what is important?
In recent years, the number of annotated noncoding RNAs (ncRNAs) and RNA-binding
proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights …
proteins (RBPs) has increased dramatically. The wide range of RBPs identified highlights …
Identification of significant chromatin contacts from HiChIP data by FitHiChIP
HiChIP/PLAC-seq is increasingly becoming popular for profiling 3D chromatin contacts
among regulatory elements and for annotating functions of genetic variants. Here we …
among regulatory elements and for annotating functions of genetic variants. Here we …