Alkaloids with antiprotozoal activity

EJ Osorio, SM Robledo, J Bastida - The alkaloids: Chemistry and biology, 2008 - Elsevier
Publisher Summary This chapter discusses the alkaloid natural products that are particularly
active against Leishmania sp., Trypanosomacruzi, Trypanosomabrucei, and Plasmodium …

Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes

HP de Koning - Trends in parasitology, 2008 - cell.com
The treatment of both human and veterinary African trypanosomiasis is still, to a large extent,
dependent on diamidines and melaminophenyl arsenicals. Sixty years after the introduction …

Aquaporins are critical for provision of water during lactation and intrauterine progeny hydration to maintain tsetse fly reproductive success

JB Benoit, IA Hansen, GM Attardo… - PLoS neglected …, 2014 - journals.plos.org
Tsetse flies undergo drastic fluctuations in their water content throughout their adult life
history due to events such as blood feeding, dehydration and lactation, an essential feature …

Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements

D Zofou, RB Nyasa, DS Nsagha, F Ntie-Kang… - Infectious Diseases of …, 2014 - Springer
Vector-borne protozoan diseases represent a serious public health challenge, especially in
the tropics where poverty together with vector-favorable climates are the aggravating factors …

Drug resistance in African animal trypanosomes: A review

A Solomon, S Workineh - African Journal of …, 2018 - research.send4journal.com
Animal African trypanosmiasis (AAT) is the most important factor contributing to the sub
potential performance of livestock. AAT is caused by Trypanosoma congolense …

Systematic review and meta-analysis on human African trypanocide resistance

KI Kasozi, ET MacLeod, SC Welburn - Pathogens, 2022 - mdpi.com
Background Human African trypanocide resistance (HATr) is a challenge for the eradication
of Human African Trypansomiaisis (HAT) following the widespread emergence of increased …

Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model

K Ndung'u, GA Murilla, JK Thuita, GN Ngae, JE Auma… - PLoS …, 2020 - journals.plos.org
We assessed the virulence and anti-trypanosomal drug sensitivity patterns of Trypanosoma
brucei rhodesiense (Tbr) isolates in the Kenya Agricultural and Livestock Research …

Comparative evaluation of rapid diagnostic test and PCR-based diagnostic assay for identification of trypanosomes in cattle of Apac and Kiryandongo districts …

D Kizza, R Azuba, E Wampande, R Okwasiimire… - BMC Veterinary …, 2024 - Springer
Background Diagnostic tests and knowledge of their diagnostic accuracies are important for
animal trypanosomosis surveillance and treatment. Methodology: A cross-sectional study …

Recent initiatives and strategies to developing new drugs for tropical parasitic diseases

CR Caffrey, D Steverding - Expert Opinion on Drug Discovery, 2008 - Taylor & Francis
Background: Despite the toll of tropical parasitic diseases on human life in the developing
world, present therapies still rely on drugs developed decades ago. In many cases, the …

Kenya Trypanosomiasis Research Institute cryobank for human and animal trypanosome isolates to support research: opportunities and challenges

GA Murilla, K Ndung'u, JK Thuita… - PLoS Neglected …, 2014 - journals.plos.org
Human African trypanosomiasis (HAT) is classified in the category of the most neglected
tropical diseases. In man, the disease is caused by two tsetse (Glossina spp.)-transmitted …