Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …

Biocatalytic site-selective (regioselective) organic transformations have been practiced for
decades, but the traditional limitations of enzymes regarding narrow substrate acceptance …

Numerous synthetic biology endeavors require well-tuned co-expression of functional
components for success. Classically, monodirectional promoters (MDPs) have been used for …

Regio‐and stereoselective oxidative hydroxylation of achiral or chiral organic compounds
mediated by synthetic reagents, catalysts, or enzymes generally leads to the formation of …

Steroids are the second largest class of drugs with a wide range of pharmacological
properties. Hydroxylation of steroids seriously affects their biological activities and other …

Filamentous fungi are the predominant source of lignocellulolytic enzymes used in industry
for the transformation of plant biomass into high-value molecules and biofuels. The rapidity …

Just like the drugs themselves, their metabolites have to be evaluated to succeed in a drug
development and approval process. It is therefore essential to be able to predict drug …

Efficient synthetic techniques for the diversification of natural products are incremental for
drug discovery processes of the pharmaceutical industry because these complex bioactive …

Purpose A number of studies have tested the hypothesis that breast cancer patients with low-
activity CYP2D6 genotypes achieve inferior benefit from tamoxifen treatment, putatively due …

Cytochromes P450 catalyze a variety of synthetically useful reactions. However, it is difficult
to determine their physiological or artificial functions when a plethora of orphan P450 …