Conformational Switch of a Peptide Provides a Novel Strategy to Design Peptide Loaded Porous Organic Polymer for Pyroptosis Pathway Mediated Cancer Therapy

S Mishra, A Sannigrahi, S Ruidas, S Chatterjee, K Roy… - Small, 2024 - Wiley Online Library
While peptide‐based drug development is extensively explored, this strategy has limitations
due to rapid excretion from the body (or shorter half‐life in the body) and vulnerability to …

[HTML][HTML] Synthesis and Physicochemical Properties of Thermally Sensitive Polymeric Derivatives of N-vinylcaprolactam

A Gola, R Pietrańczyk, W Musiał - Polymers, 2024 - mdpi.com
Six derivatives of poly-N-vinylcaprolactam (PNVCL) P1-P6 were synthesized via surfactant-
free precipitation polymerization (SFPP) at 70° C, with potassium persulfate (KPS) as the …

Analyzing the impact of substitution on the temperature-sensitive release of doxorubicin in an imine-based covalent organic framework using molecular dynamics

M Darparesh, R Ghadari - Computational Materials Science, 2024 - Elsevier
Nowadays, drug release through temperature control between healthy and cancer cells is
also one of the most critical topics in drug delivery. Covalent organic frameworks (COFs) …