Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …

Introduction: Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid
synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a …

Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …

Decades of preclinical and natural history studies have highlighted the potential of fatty acid
synthase (FASN) as a bona fide drug target for oncology. This review will highlight the …

Metabolic alteration for adaptation of the local environment has been recognized as a
hallmark of cancer. GNPAT dysregulation has been implicated in hepatocellular carcinoma …

Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …

Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …

Cancer cells undergo alterations in lipid metabolism to support their high energy needs,
tumorigenesis and evade an anti-tumor immune response. Alterations in fatty acid …