The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on
histones, DNA, and RNA have emerged as three important building blocks of epigenetic …

Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …

Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …

Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host
defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 …

methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The
ideal method for 5mC localization would be both nondestructive of DNA and direct, without …

Ten-eleven translocation (TET) proteins are iron-dependent and α-ketoglutarate-dependent
dioxygenases that sequentially oxidize the methyl group of 5-methylcytosine (5mC) to 5 …

As a bona fide epigenetic marker, DNA methylation has been linked to the differentiation
and function of regulatory T (Treg) cells, a subset of CD4 T cells that play an essential role in …

Abstract Benzo (a) pyrene (BaP), the earliest and most significant carcinogen among
polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and …

Background In diabetic retinopathy, increasing evidence points to a link between the
pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 …

Genetic information is not transmitted solely by DNA but by the epigenetics process.
Epigenetics describes molecular missing link pathways that could bridge the gap between …