Werner syndrome protein (WRN) is one of a family of five human RecQ helicases implicated
in the maintenance of genome stability. The conserved RecQ family also includes RecQ1 …

The numerous processes that damage DNA are counterbalanced by a complex network of
repair pathways that, collectively, can mend diverse types of damage. Insights into these …

DNA repair declines with age and correlates with longevity in many animal species. In this
study, we investigated the effects of GAL4-induced overexpression of genes implicated in …

Aging is a natural and unavoidable part of life. However, aging is also the primary driver of
the dominant human diseases, such as cardiovascular disease, cancer, and …

Aging is a global challenge. Many studies reported that the accumulation of ROS and
oxidative stress could be the most important causative factors for aging. Phenolic …

Werner syndrome (WS) is a rare genetic disease in humans, caused by mutations in the
WRN gene that encodes a protein containing helicase and exonuclease domains. WS is …

Human ageing is the gradual decline in organ and tissue function with increasing
chronological time, leading eventually to loss of function and death. To study the processes …

Exonucleases are key enzymes involved in many aspects of cellular metabolism and
maintenance and are essential to genome stability, acting to cleave DNA from free ends …

Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular
level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID …

DNA helicases are ubiquitous enzymes that catalyze unwinding of duplex DNA and function
in all metabolic processes in which access to single-stranded DNA is required, including …