C-type lectins in immunity and homeostasis

GD Brown, JA Willment, L Whitehead - Nature Reviews Immunology, 2018 - nature.com
The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …

Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023 - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer

JH van Puffelen, ST Keating, E Oosterwijk… - Nature Reviews …, 2020 - nature.com
Intravesical BCG instillation is the gold-standard adjuvant immunotherapy for patients with
high-risk non-muscle-invasive bladder cancer. However, the precise mechanism of action by …

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

CJ Queval, R Brosch, R Simeone - Frontiers in microbiology, 2017 - frontiersin.org
Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

The Mycobacterium tuberculosis capsule: a cell structure with key implications in pathogenesis

R Kalscheuer, A Palacios, I Anso, J Cifuente… - Biochemical …, 2019 - portlandpress.com
Bacterial capsules have evolved to be at the forefront of the cell envelope, making them an
essential element of bacterial biology. Efforts to understand the Mycobacterium tuberculosis …

Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche

Y Henlon, K Panir, I McIntyre, C Hogg, P Dhami… - Proceedings of the …, 2024 - pnas.org
Endometriosis negatively impacts the health-related quality of life of 190 million women
worldwide. Novel advances in nonhormonal treatments for this debilitating condition are …

T cell antifungal immunity and the role of C-type lectin receptors

EA Speakman, IM Dambuza, F Salazar, GD Brown - Trends in immunology, 2020 - cell.com
Fungi can cause disease in humans, from mucocutaneous to life-threatening systemic
infections. Initiation of antifungal immunity involves fungal recognition by pattern recognition …

Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis

M Holzheimer, J Buter, AJ Minnaard - Chemical reviews, 2021 - ACS Publications
The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

[HTML][HTML] Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors

M Nagata, K Toyonaga, E Ishikawa, S Haji… - Journal of Experimental …, 2021 - rupress.org
Helicobacter pylori causes gastritis, which has been attributed to the development of H.
pylori–specific T cells during infection. However, the mechanism underlying innate immune …

Recognition of mycobacterial lipids by immune receptors

E Ishikawa, D Mori, S Yamasaki - Trends in immunology, 2017 - cell.com
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), infects one-third
of the world's population and causes 1.5 million deaths each year. The cell envelopes of …