Eukaryotic voltage-gated sodium (Nav) channels contribute to the rising phase of action
potentials and served as an early muse for biophysicists laying the foundation for our current …

Numerous structurally and functionally unrelated drugs block the hERG potassium channel.
HERG channels are involved in cardiac action potential repolarization, and reduced function …

Ion channels are well recognized as important therapeutic targets for treating a number of
different pathophysiologies. Historically, however, development of drugs targeting this …

Voltage-gated ion channels regulate many physiological functions and are targets for a
number of drugs. Patch-clamp electrophysiology is the standard method for measuring …

Background: Variants in ion channel genes have classically been studied in low throughput
by patch clamping. Deep mutational scanning is a complementary approach that can …

Ion channels regulate a variety of physiological processes and represent an important class
of drug target. Among the many methods of studying ion channel function, patch clamp …

A series of benzodiazepines and benzazepinones were synthesized and evaluated as
potential sodium channel blockers in a functional, membrane potential-based assay. One …

Voltage-gated sodium (Nav) channels are essential contributors to neuronal excitability,
making them the most commonly targeted ion channel family by toxins found in animal …

Drugs that block voltage-gated sodium channels are efficacious in the management of
neuropathic pain. Accordingly, this class of ion channels has been a major focus of …

The purpose of this chapter is to provide a brief introduction to the anatomy and physiology
of pain pathways from peripheral nociceptors to central nervous system areas involved in …