Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

Summary VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-
anchored protein that helps generate tethers between the ER and other membranes through …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2), which comprises only about 1% of
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …

Plasma membrane phosphatidylinositol (PI) 4-phosphate (PtdIns4P) has critical functions
via both direct interactions and metabolic conversion to PI 4, 5-bisphosphate (PtdIns (4, 5) …

Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their
principal role is instructional: they interact with proteins. Each cellular membrane …

One of the early surprises in the study of cell adhesion was the discovery that β-catenin
plays dual roles, serving as an essential component of cadherin-based cell–cell adherens …

Abstract Phosphatidylinositol-4, 5-bisphosphate (PtdIns (4, 5) P2) has an important function
in cell regulation both as a precursor of second messenger molecules and by means of its …

The basic effector domain of myristoylated alanine-rich C kinase substrate (MARCKS), a
major protein kinase C substrate, binds electrostatically to acidic lipids on the inner leaflet of …

The protein kinase family is large and important, but it is only one family in a larger
superfamily of homologous kinases that phosphorylate a variety of substrates and play …