Cellular immune responses in the pathophysiology of preeclampsia

D Miller, K Motomura, J Galaz… - Journal of Leukocyte …, 2022 - academic.oup.com
Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at
20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality …

Neurodevelopmental outcomes of prenatal preeclampsia exposure

SB Gumusoglu, ASS Chilukuri, DA Santillan… - Trends in …, 2020 - cell.com
Preeclampsia is a dangerous hypertensive disorder of pregnancy with known links to
negative child health outcomes. Here, we review epidemiological and basic neuroscience …

Review of the immune mechanisms of preeclampsia and the potential of immune modulating therapy

YC Ai-ris, LA Smith, SA Karumanchi - Human immunology, 2021 - Elsevier
Successful pregnancy relies on maternal immunologic tolerance mechanisms limit
maladaptive immune responses against the semi-allogeneic fetus and placenta and support …

The serotonin-immune axis in preeclampsia

S Gumusoglu, S Scroggins, J Vignato… - Current hypertension …, 2021 - Springer
Abstract Purpose of Review To review the literature and detail the potential immune
mechanisms by which hyperserotonemia may drive pro-inflammation in preeclampsia and to …

[HTML][HTML] Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice

JA Sandgren, G Deng, DW Linggonegoro… - JCI insight, 2018 - ncbi.nlm.nih.gov
Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human
pregnancies complicated by preeclampsia (PE), and AVP infusion throughout gestation is …

New immune horizons in therapeutics and diagnostic approaches to Preeclampsia

I Mukherjee, S Singh, A Karmakar… - American Journal of …, 2023 - Wiley Online Library
Hypertensive disorders of pregnancy (HDP) are one of the commonest maladies, affecting
5%–10% of pregnancies worldwide. The American College of Obstetricians and …

Chronic maternal interleukin-17 and autism-related cortical gene expression, neurobiology, and behavior

SB Gumusoglu, BWQ Hing, ASS Chilukuri… - …, 2020 - nature.com
Chronic inflammation during pregnancy (eg, preeclampsia, diabetes) is linked to increased
risk for offspring neurodevelopmental disorders such as autism spectrum disorder (ASD) …

Animal models of cardiovascular complications of pregnancy

Z Arany, D Hilfiker-Kleiner, SA Karumanchi - Circulation research, 2022 - Am Heart Assoc
Cardiovascular complications of pregnancy have risen substantially over the past decades,
and now account for the majority of pregnancy-induced maternal deaths, as well as having …

Animal models of preeclampsia: mechanistic insights and promising therapeutics

EB Taylor, EM George - Endocrinology, 2022 - academic.oup.com
Preeclampsia (PE) is a common pregnancy-specific disorder that is a major cause of both
maternal and fetal morbidity and mortality. Central to the pathogenesis of PE is the …

Arginine vasopressin and posterior reversible encephalopathy syndrome pathophysiology: the missing link?

B Largeau, O Le Tilly, B Sautenet… - Molecular …, 2019 - Springer
Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological entity
characterized by a typical brain edema. Its pathogenesis is still debated through …