The Notch signaling pathway is known to be responsible for maintaining a balance between
cell proliferation and death and, as such, plays important roles in the formation of many …

Since the cancer stem cell concept has been widely accepted, several strategies have been
proposed to attack cancer stem cells (CSC). Accordingly, stem cell markers are now …

In human glioblastomas (hGBMs), tumor-propagating cells with stem-like characteristics
(TPCs) represent a key therapeutic target. We found that the EphA2 receptor tyrosine kinase …

Introduction Some molecular subtypes of breast cancer have preferential sites of distant
relapse. The protein expression pattern of the primary tumor may influence the first distant …

Aim Gliomas represent the most frequent neoplasm of the central nervous system.
Unfortunately, surgical cure of it is practically impossible and their clinical course is primarily …

Glioblastoma is an invasive tumor of the central nervous system. Tumor recurrence resulting
from ineffective current treatments, mainly due to the blood–brain barrier, highlights the need …

Glioblastomas (GBM) are associated with high rates of relapse. These brain tumors are often
resistant to chemotherapies like temozolomide (TMZ) and there are very few treatment …

Cell cycle control and migration are critical processes during development and maintenance
of tissue functions. Recently, primary cilia were shown to take part in coordination of the …

Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to
treatment, and characterized by a high degree of anaplasia and proliferation. Routine …

Glioblastoma Multiforme (GBM) is an incurable malignancy. GBM patients have a short life
expectancy despite aggressive therapeutic approaches based on surgical resection …