Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Obesity develops when energy intake exceeds energy expenditure over time. Numerous
neurotransmitters, hormones, and factors have been implicated to coordinately control …

Over the past two centuries, prevalent models of energy and glucose homeostasis have
emerged from careful anatomical descriptions in tandem with an understanding of cellular …

Neurons within the central nervous system receive humoral and central (neurotransmitter or
neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent …

Besides the classical ones (support/protection, hematopoiesis, storage for calcium, and
phosphate) multiple roles emerged for bone tissue, definitively making it an organ …

Human monogenic obesity syndromes, including Bardet-Biedl syndrome (BBS), implicate
neuronal primary cilia in regulation of energy homeostasis. Cilia in hypothalamic neurons …

Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in
discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. NPY …

Neuropeptide Y (NPY) exerts a powerful orexigenic effect in the hypothalamus. However,
extra-hypothalamic nuclei also produce NPY, but its influence on energy homeostasis is …

The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

The neuropeptide Y (NPY) system–comprising of neuropeptide Y, peptide YY, pancreatic
polypeptide and the corresponding Y receptors through which they act (Y1, Y2, Y4, Y5 and …