There are at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled. CB1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …
G Colombo, R Agabio, G Diaz, C Lobina, R Reali… - Life sciences, 1998 - Elsevier
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 …
The enteric nervous system of several species, including the mouse, rat, guinea pig and humans, contains cannabinoid CB1receptors that depress gastrointestinal motility, mainly by …
We have studied the effect of cannabinoid agonists (CP 55,940 and cannabinol) on intestinal motility in a model of intestinal inflammation (induced by oral croton oil in mice) …
A Giuffrida, M Beltramo, D Piomelli - Journal of Pharmacology and …, 2001 - ASPET
The endocannabinoids, a family of endogenous lipids that activate cannabinoid receptors, are released from cells in a stimulus-dependent manner by cleavage of membrane lipid …
The therapeutic actions of cannabinoids have been known for centuries. In the last 25 years this area of research has grown exponentially with the discovery of specific cannabinoid …
GD Carlo, AA Izzo - Expert opinion on investigational drugs, 2003 - Taylor & Francis
Δ9-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of …
L Pinto, AA Izzo, N Mascolo, F Capasso, MG Cascio… - Gastroenterology, 2002 - Elsevier
Background & Aims: Activation of enteric cannabinoid CB1 receptors inhibits motility in the small intestine; however, it is not known whether endogenous cannabinoids (anandamide …
T Croci, L Manara, G Aureggi… - British journal of …, 1998 - Wiley Online Library
We investigated the effect of the cannabinoid agonist (+) WIN552122 on human ileum longitudinal smooth muscle preparations, either electrically stimulated or contracted by …