In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this
review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is …

Tumor-associated myeloid cells modulate the tumor microenvironment and affect tumor
progression. Type I interferon (IFN-I) has multiple effects on tumors and immune response …

Seven tumor necrosis factor receptor‐(TNFR‐) associated factors (TRAFs) have been found
in mammals, which are primarily involved in the signal translation of the TNFR superfamily …

Necroptosis is a programmed, caspase-independent cell death that is morphologically
similar to necrosis. TNF-induced necroptosis is mediated by receptor-interacting protein …

Objectives The inflammatory cascade and cell death post-myocardial ischemia reperfusion
(MI/R) are very complex. Despite the understanding that macrophage inflammation has a …

Deletion of TRAF2 or TRAF3 in B cells prolongs their survival. However, it remains unknown
whether deletion of such factors affects B cells' ability to tolerate DNA damage, which can be …

Background. The main purpose of this study was to explore the predictive value of the
systemic immune inflammation index (SII), a novel clinical marker, in heart failure (HF) …